Well, you can do a couple of things. You can take the plunge, hope for the best and persevere or you can do what I recommend and check out some graphic novels first until you see a series starting at issue #1 you might want to try. Additionally, some companies like Marvel do Point One issues where a new comer can start reading the series. These comics begin a new story arc and no prior knowledge is usually required (e.g. Spider-Man #679.1). DC Comics recently rebooted all their comics back to issue #1, so they’re all no further than issue 8 at present.
‘Words and pictures are yin and yang. Married, they produce a progeny more interesting than either parent.’ – Dr. Suess.